Title: Clinical Pharmacologist | Remote

Company: Crossing Hurdles
Location: Canada
Job Type: FullTime


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Description:

This job posting is for a PK/PD Module expert in Translational/Clinical Pharmacology Decision-Making. The position is an hourly contract with a compensation range of $175-$250 per hour. The work location is remote, and the commitment is between 10-40 hours per week.

Role Responsibilities

  • Author high-quality ("golden") First-in-Human (FIH) dose rationales and escalation strategies for representative drug programs.
  • Translate real-world translational pharmacology decision-making into structured guidance suitable for AI training and evaluation.
  • Encode senior-level decision heuristics and trade-offs underlying dose selection (safety, PK/PD, potency, MoA, speed-to-proof).
  • Develop clear decision rules and scoring rubrics to distinguish acceptable, unsafe, or incomplete dose rationales.
  • Surface implicit judgment calls, including when experienced teams override model-based recommendations.
  • Review provided nonclinical and clinical data packages (tox, PK/PD, exposure--response) to inform decision frameworks.

    • Requirements

  • Strong experience in translational or clinical pharmacology within major biopharma, biotech, or specialized consulting.
  • Direct accountability for FIH starting dose, SAD/MAD design, and/or Phase 2 dose selection across multiple assets.
  • Demonstrated governance experience, including participation in review boards, IND sign-off, or regulatory-facing dose justifications.
  • Proven ability to balance nonclinical and clinical inputs (tox, PK, PD, potency, MoA) under uncertainty.
  • Strong written communication skills with the ability to convert expert judgment into explicit rules and rubrics.
  • Decision-maker mindset with hands-on ownership, not solely a modeling or analytical background.

    • Application Process (Takes 20 Min)

  • Upload resume
  • Interview (15 min)
  • Submit form


    • Apply Now  



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